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. 2022 Nov 25;10:1037051. doi: 10.3389/fbioe.2022.1037051

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Copyright © 2022 Wang, Wu and Senyo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemical structures of cationic lipids, ionizable lipids, and polymers. DOTMA: 1,2-di-O-octadecenyl-3-trimethylammonium-propane. DOTAP: 1,2-dioleoyl-3-trimethylammonium-propane. DOSPA: 2,3-dioleyloxy-N-[2-(sperminecarboxamido)ethyl]-N,N-dimethyl-1-propanaminium trifluoroacetate. DOGS: 2,5-bis(3-aminopropylamino)-N-[2-[di(heptadecyl)amino]-2-oxoethyl] pentanamide. DLin-MC3-DMA: heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino) butanoate. cKK-E12: 3,6-bis(4-(bis(2-hydroxydodecyl)amino)butyl)piperazine-2,5-dione. C12-200: 1,1′-[[2-[4-[2-[[2-[bis(2-hydroxydodecyl)amino]ethyl](2-hydroxydodecyl)amino]ethyl]-1-piperazinyl]ethyl]imino]bis-2-dodecanol. PLGA, poly(lactic-co-glycolic acid); PEI, poly-ethylenimine; PAMAM, poly(amidoamine).