Fig. 6.

knockdown of CHCHD4 suppressed the growth of xenograft tumours in nude mice by inhibiting the MYC pathway. After A549 cells treated with sh-CHCHD4 were injected into each mouse, A the xenograft tumour, the tumour weight (B) and volume (C) were pictured and examined; the histopathological changes in tumour tissues were observed using HE staining (D); the protein levels of Ki67 in tumour tissues were evaluated using immunohistochemistry (E); apoptosis in tumour tissues was assessed using the TUNEL assay (F); MYC expression in tumour tissues was examined using western blot (G). H Proposed model of USF1-CHCHD4 axis modulating LUAD. ^*P < 0.05