Table 2.
Adherence to abiraterone or enzalutamide in the whole period of observation.
| Parameter | Abiraterone cohort (n = 86) |
Enzalutamide cohort (n = 148) |
All patients (n = 234) |
P
value |
|---|---|---|---|---|
| Assessed cycles | ||||
| n (%) | 669 (38) | 1070 (62) | 1739 | |
| Median, n [IQR] | 8 [4-12] | 7 [4-12] | 7 [4-12] | .239 |
| Pill counting | ||||
| Non-adherencea, pills n (%) | 1.941/37.184 (5.2) | 4.939/117.096 (4.2) | 6.880/154.280 (4.5) | <.001 |
| Non-adherenceb, median % [IQR] | 3.1 [10.2/0.0] | 2.2 [5.4/0.9] | 2.4 [7.3/0.7] | .517 |
| Compliance, dose reduction, pts, n (%) | 1 (1) | 10 (7) | 11 (5) | .0513 |
| Dose reduction, median % [IQR] | 50 [NA] | 25 [25-50] | 30 [25-50] | |
| BAAS (patient’s reporting) | ||||
| Patients missing, n (%) | 12 (14) | 38 (26) | 50 (21) | .052 |
| Missing eventsc, n (%) | 23 (3.5) | 90 (8.8) | 113 (6.8) | .031 |
| Missing reasons, n (%) | ||||
| Forgot | 4 (17) | 38 (42) | 42 (37) | <.001 |
| Do not need it | 8 (35) | 22 (24) | 30 (27) | |
| Quantity | 0 (0) | 0 (0) | 0 (0) | |
| Other | 11 (48) | 30 (33) | 41 (36) | |
| Clinical diary | ||||
| Non-adherenced, patients n (%) | 20 (35) | 33 (31) | 53 (29) | .6072 |
| Non-compliancee, patients n (%) | 29 (34) | 42 (28) | 71 (30) | .3914 |
Bold indicates statistically significant values.
Based on the proportion of missed/prescribed pills ratio.
Proportions based on missed/prescribed pills ratio, reported as the median (and IQR) of individual proportions over the treatment period.
Proportions based on reported missing events/total number of cycles ratio.
Proportions based on fulfilled/delivered diary ratio in patients completing at least one diary.
Patients not completing any of the diaries delivered.
Abbreviations: IQR, interquartile range; m, months; n, number; NA, not assessable.