Table 5.
The absolute abundance of functions with statistical difference between groups.
| Function | OA | Control | p | Q |
|---|---|---|---|---|
| COG0745 | 201,561## | 221,739## | 0.002* | 0.028& |
| COG1309 | 159,156 ± 30,575# | 178,693 ± 22,198# | 0.002* | 0.029& |
| COG0583 | 147,960## | 190,206## | <0.001** | 0.038& |
| COG2814 | 120,424 ± 30,219# | 105,038 ± 30,318# | 0.026* | 0.025& |
| COG0451 | 113,247## | 92,398## | <0.001** | 0.034& |
| COG1670 | 94,183## | 80,466## | <0.001** | 0.006& |
| COG0834 | 62,511## | 80,843## | 0.008* | 0.046& |
| COG2197 | 82,243## | 59,843## | 0.018* | 0.020& |
| EC:2.7.13.3 | 156,797 ± 30,898# | 170,494 ± 20,685# | 0.022* | 0.004 |
| EC:3.6.3.14 | 77,826## | 87,594## | 0.032* | 0.017& |
| EC:3.6.3.17 | 54,789## | 77,270## | 0.021* | 0.034& |
| EC:3.5.1.28 | 74,091 ± 12,058# | 62,421 ± 8,864# | <0.001** | 0.002& |
| EC:2.2.1.1 | 54,671 ± 11,447# | 59,216 ± 6,464# | 0.032* | 0.043& |
| K00615 | 54,670 ± 11,447# | 59,216 ± 6,464# | 0.032* | 0.043& |
| K06889 | 57,086## | 49,012## | 0.027* | 0.010& |
| K01448 | 53,281 ± 9,737# | 46,816 ± 6,746# | 0.001* | 0.002& |
| K07025 | 53,809## | 46,720## | <0.001** | 0.019& |
| PWY-2942 | 54,670 ± 11,447# | 59,216 ± 6,464# | 0.032* | 0.043& |
| PWY-5103 | 30,745## | 30,916## | 0.027* | 0.010& |
| PWY-7220 | 53,281 ± 9,737# | 46,816 ± 6,746# | 0.001* | 0.002& |
| PWY4FS-7 | 26,652## | 30,609## | <0.001** | 0.019& |
| PF00486 | 206,948## | 224,016## | 0.020* | 0.015& |
| PF00534 | 201,035 ± 27,455# | 188,176 ± 21,392# | 0.022* | 0.046& |
| PF00132 | 189,164## | 181,314## | 0.007* | 0.003& |
| PF03466 | 151,293## | 191,960## | <0.001** | 0.034& |
| TIGR01484 | 95,285 ± 22,620# | 113,310 ± 15,989# | <0.001** | 0.042& |
| TIGR01726 | 63,149## | 81,207## | 0.008* | 0.037& |
| TIGR01003 | 48,491 ± 17,615# | 59,381 ± 10,966# | 0.001* | 0.042& |
| TIGR00517 | 51,602 ± 7,977# | 55,620 ± 4,532# | 0.007* | 0.012& |
| TIGR00093 | 45,961 ± 8,023# | 50,890 ± 5,906# | 0.002* | 0.025& |
| TIGR00813 | 42,018## | 35,095## | 0.013* | 0.003& |
| TIGR00657 | 42,063 ± 5,555# | 38,553 ± 4,467# | 0.003* | 0.012& |
COG0745: DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain; COG1309: DNA-binding transcriptional regulator, AcrR family; COG0583: DNA-binding transcriptional regulator, LysR family; COG2814: Predicted arabinose efflux permease, MFS family; COG0451: Nucleoside-diphosphate-sugar epimerase; COG1670: Protein N-acetyltransferase, RimJ/RimL family; COG0834: ABC-type amino acid transport/signal transduction system, periplasmic component/domain; COG2197: DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains; EC:2.7.13.3: Histidine kinase; EC:3.6.3.14: H(+)-transporting two-sector ATPase; EC:3.6.3.17: Monosaccharide-transporting ATPase; EC:3.5.1.28: N-acetylmuramoyl-L-alanine amidase; EC:2.2.1.1: Transketolase; K00615: transketolase; K06889: uncharacterized protein; K01448: N-acetylmuramoyl-L-alanine amidase; K07025: putative hydrolase of the HAD superfamily; PWY-2942: L-lysine biosynthesis III; PWY-5103: L-isoleucine biosynthesis III; PWY-7220: adenosine deoxyribonucleotides de novo biosynthesis II; PWY4FS-7: phosphatidylglycerol biosynthesis I (plastidic); PF00486: Transcriptional regulatory protein, C terminal; PF00534: Glycosyl transferases group 1; PF00132: Bacterial transferase hexapeptide (six repeats); PF03466: LysR substrate binding domain; TIGR01484: HAD hydrolase, family IIB; TIGR01726: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; TIGR01003: phosphocarrier, HPr family; TIGR00517: acyl carrier protein; TIGR00093: pseudouridine synthase; TIGR00813: transporter, solute:sodium symporter (SSS) family; TIGR00657: aspartate kinase. OA, osteoarthritis; Q, p value after adjusting for gender, age, and body mass index (BMI).
mean±standard deviation.
median.
p < 0.05, statistical difference.
p < 0.001, dramatically statistical difference; and & Q < 0.05, statistical difference.