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. 2022 Nov 25;10:1053139. doi: 10.3389/fcell.2022.1053139

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Copyright © 2022 Turner and Mathias.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HCMV lytic replication proceeds sequentially through 10 checkpoints, with completion of each essential for production of infectious virions. These are 1) entry, 2) early gene expression, 3) RC biogenesis, 4) viral genome replication, 5) late gene expression, 6) vAC biogenesis, 7) capsid assembly and maturation, 8) nuclear egress, 9) envelopment, and 10) cellular egress. IE, immediate early; DE, delayed early; DNA pol, viral DNA polymerase complex; RC, replication compartment;, PIC, pre-initiation complex; vPIC, viral pre-initiation complex; pol II, RNA polymerase II complex; TRM, tripartite terminase complex; NEC, nuclear egress complex; vAC, viral assembly compartment.