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. 2022 Nov 25;10:1053139. doi: 10.3389/fcell.2022.1053139

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Copyright © 2022 Turner and Mathias.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Viral DNA replication proceeds by a rolling circle mechanism to produce linear concatemers. The tripartite helicase-primase complex composed of UL70, UL102 and UL105 separates the strands to form a replication fork, while the DNA polymerase (UL54) and processivity factor (UL44) synthesise the daughter strands by leading and lagging strand synthesis. The ssDNA binding protein UL57 forms filaments on ssDNA, which stimulates polymerase and primase activity. ssDNA, single stranded DNA.