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. 2022 Nov 25;10:1053139. doi: 10.3389/fcell.2022.1053139

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Copyright © 2022 Turner and Mathias.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The HCMV vAC is a cytoplasmic virus factory where virion cargo accumulates to enable tegumentation and secondary envelopment. The vAC is characterised by concentric rings of host-derived organelles, with endosome membranes surrounded by a Golgi ring, and the ER loosely associated around the periphery. The structure is adjacent to the enlarged kidney-shaped nucleus and functions as a Golgi-derived MTOC. The cytoskeleton is central to vAC formation and function, and is connected to the nucleus through polarised LINC complexes. LINC complexes provide a bridge between the nucleoskeleton and cytoskeleton that allows the vAC to exert control over nuclear morphology, rotation, and internal organisation. ER, endoplasmic reticulum; EE, early endosome; MT, microtubule; MTOC, microtubule organising centre; LINC, linker of nucleoskeleton and cytoskeleton; vAC, viral assembly compartment; RC, replication compartment.