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. 2022 Dec 8;13:7582. doi: 10.1038/s41467-022-35256-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — IL18 is an adipokine from brown adipocytes in BAT and beige cells in SAT. NCC mediates IL18 functions in activating thermogenesis by regulating mitochondrial functions and lipolysis in BAT in cooperation with β3-AR. IL18r mediates IL18 activities in promoting glucose tolerance and insulin sensitivity by regulating IR-AKT insulin signaling and GLUT4-mediated glucose metabolism in EAT. IL18 signaling in adipocytes protects mice from obesity, insulin resistance and adipose tissue inflammation.