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. 2022 Nov 23;25(12):105662. doi: 10.1016/j.isci.2022.105662

Figure 4.

Figure 4

S100A8 supplementation improves survival rates in mice with obesity and diabetes during endotoxemia

db/db and db/+ mice at 8 weeks of age were used for experiments (A–C).

(A) The survival rates, (B) body temperature, and (C) blood glucose levels of mice injected with either PBS or S100A8 (0.1 μg/gBW) 1 h after LPS (12.5 μg/gBW) stimulation were measured at 12, 24, 36, and 48 h (n = 13).

ob/ob and wild-type (WT) mice at 8 weeks of age were used for experiments (D–F).

(D) The survival rates, (E) body temperature, and (F) blood glucose levels of mice injected with either PBS or S100A8 (0.1 μg/gBW) 1 h after LPS (12.5 μg/gBW) stimulation were measured at 12, 24, 36, and 48 h (n = 10).

C57BL/6J mice fed a Western diet (WD) or normal diet (ND) from 8 to 16 weeks of age were used for experiments (G–I).

(G) The survival rates, (H) body temperature, and (I) blood glucose levels of mice injected with either PBS or S100A8 (0.1 μg/gBW) 1 h after LPS (12.5 μg/gBW) stimulation were measured at 12, 24, and 36 h (n = 10).

All data from three independent experiments are represented as the mean ± SEM ∗p < 0.05, ∗∗p < 0.01.