REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
PE Rat Anti-Mouse Ly-6G and Ly-6C Clone RB6-8C5	Beckton Dickinson	Cat# 561084; RRID: AB_394644
Ms F4/80-Like Rcptr Alexa 488 6F12	Beckton Dickinson	Cat# 564227; RRID: AB_2738682
Chemicals, peptides, and recombinant proteins
RNeasy Mini Kit	QIAGEN	Cat# 74106
High-Capacity cDNA Reverse Transcription Kit	Thermo Fisher Scientific	Cat# 4368813
THUNDERBIRD SYBR qPCR Master Mix	TOYOBO	Cat# QPS-101
LPS	SantaCruz	Cat# sc3535a
Recombinant Mouse S100A8 Protein,CF	R&D	Cat# 9877-S8-050
Recombinant Mouse S100A8/S100A9 Heterodimer Protein,CF	R&D	Cat# 8916-S8-050
MF diet	Oriental Yeast	Cat# orien-mf500
Western diet	Research Diets, Inc	Cat# D12079B
CRX-527	Invivogen	Cat# tlrl-crx527
Critical commercial assays
TNF alpha Mouse Uncoated ELISA Kit with Plates	eBioscience	Cat# 88-7324-22
IL-6 Mouse Uncoated ELISA Kit with Plates	eBioscience	Cat# 88-7064-22
IL-1 beta Mouse Uncoated ELISA Kit with Plates	eBioscience	Cat# 88-7013-22
Mouse S100A8 ELISA Kit	Abcam	Car# ab213886
TG assay kit	FUJIFILM Wako Pure Chemical Corporation	Cat# 467-08994
Aspartate aminotransferase assay kit	FUJIFILM Wako Pure Chemical Corporation	Cat# 631-22751
Alanine aminotransferase assay kit	FUJIFILM Wako Pure Chemical Corporation	Cat# 638-22761
Cholesterol assay kit	FUJIFILM Wako Pure Chemical Corporation	Cat# 635-50981
Glutest Neo Super	Sanwa Chemical Co.	N/A
Experimental models: Cell lines
Hepa 1-6	RIKEN Bioresource Center	RCB1638
Experimental models: Organisms/strains
Mouse: WT C57BL6/J	Jackson Laboratory	JAX. 000664
Mouse: BKS.Cg-m+/+Leprdb/Jcl (Db/m)	Jackson Laboratory	JAX. 000662
Mouse: BKS.Cg- + Leprdb/+Leprdb/Jcl (Db/db)	Jackson Laboratory	JAX. 000642
Mouse: B6.V-Lepob/J	Jackson Laboratory	JAX. 000632
Mouse: B6(Cg)-Tlr4tm1.2Karp/J	Jackson Laboratory	JAX. 029015
Mouse: B6.129P2-Lyz2tm1(cre)Ifo/J	Jackson Laboratory	JAX. 004781
Oligonucleotides
Primers for qPCR, see Table S1	This paper	N/A
Software and algorithms
Prism 8 software (GraphPad Software)	https://www.graphpad.com/scientific-software/prism/	N/A
JMP 16	https://www.jmp.com/ja_jp/home.html	N/A
Other
7900 Real-Time PCR System	Applied Biosystems	N/A
FACS Canto II	BD biosciences	N/A
Rectal thermometer	Natsume Seisakusho Co.	KN-91-AD-1687-M