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. 2022 Nov 25;13:1064872. doi: 10.3389/fphar.2022.1064872

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Copyright © 2022 Liu, Dou, Wei, Zhang, Xiong, Wen, Xiang, Chen, Zhang, Altamirano, Chen, Zhang and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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UEE affected the concentrations of occludin and ZO-1. (A) UEE increased the expression of ZO-1; (B) UEE increased the concentration of occludin; and (C) potential correlation analysis between the intestinal flora associated with AS and pharmacokinetic markers. Rectangles represent the intestinal flora related to AS; circles denote pharmacokinetic markers; red indicates a positive association, whereas blue indicates a negative correlation. Results are expressed as the mean ± SD (n = 3 per group). ^* p < 0.05, ^** p < 0.01.