FIG. 2.
MAb C3.1 transfers protection against disseminated candidiasis. (A) Mice given unheated MAb C3.1 (C3.1), H-C3.1, A-C3.1, or DPBS (buffer diluent) i.p.; (B) mice given MAb C3.1, MAb B6.1, or DPBS as a control. In both panels, the animals were challenged i.v. with 5 × 105 viable yeast cells, and susceptibility to disseminated disease was assessed by determining kidney CFU (A) and by survival curves (B). (A) Mice that received the unheated or heated MAb C3.1 had 86 and 88% fewer CFU, respectively, than mice that received DPBS (P < 0.001). Mice that were given the absorbed serum developed almost the same number of CFU as mice that received DPBS (control). Bars show standard errors. (B) Mice given MAb C3.1 had survival times similar to those of mice given MAb B6.1. Their mean survival times were significantly longer than for animals given DPBS (P < 0.05).