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. 2022 Jan 10;118(15):3112–3125. doi: 10.1093/cvr/cvab375

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© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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[A(i)], Model APs at baseline (dashed line) and typical responses to 30% IKr reduction. NR (red) shows modest AP prolongation, HR (green) shows failure of repolarization. EAD (grey) responses (defined here as positive deflection of membrane potential ≥10% of AP amplitude) are also shown. [A(ii)] Violin plot comparison of mean ion channel conductance for each AP subgroup. [B(i)] Example traces of two typical AP responses to 60% ICa(L) block. Baselines (dashed lines) and 10%^ile (blue) and 90%^ile (red) responses are shown. [B(ii)] Violin plot comparison of typical ion channel conductance in low (10%^ile) and high (90%^ile) responders to ICa(L) block.