FIG. 3.

Inhibitory effects of various peptides, alone or in combination with LPS core-specific MAb (WN1 222-5) on the uptake of FITC-conjugated E. coli O111:B4 LPS by CHO-CD14 cells (left side of figure) and by PBMC (right side of figure). See Fig. 2 legend for experimental procedures, except that NHS was held constant in this experiment at 10% (vol/vol) and WN1 222-5 was introduced at various concentrations as shown. Panels A to D document the influence of PMB, SAEP-4, SAEP-2, and “nonsense peptide,” respectively, on the cell uptake of LPS. The P values shown in parentheses below each horizontal axis indicate the statistical significance, as determined by two-way ANOVA, of differences in MFI produced by the material specified for that axis. N.S., not significant (P > 0.05).