FIG. 5.

Inhibitory effect of various peptides, alone or in combination with LPS core-specific MAb (WN1 222-5), on LPS-induced IL-6 production by CHO-CD14 cells (left side of figure) and by human PBMC (right side of figure). See Fig. 4 legend for experimental procedures, except that in this experiment the concentration of NHS was held constant at 10% (vol/vol), and the concentration of WN1 222-5 was varied as indicated. The data shown are representative of those obtained in three similar experiments. Panels A to D document the influence of PMB, SAEP-4, SAEP-2, and “nonsense peptide,” respectively, on LPS-induced IL-6 release. The P values shown in parentheses below each horizontal axis indicate the statistical significance, as determined by two-way ANOVA, of differences in IL-6 concentration produced by the material specified for that axis. N.S., not significant (P > 0.05).