FIG. 6.

Inhibitory effects of various peptides, alone or in combination with LPS core-specific MAb (WN1 222-5), on LPS-induced TNF-α production by human PBMC. See Fig. 4 legend for experimental procedures, except for the following: (i) in this experiment the concentration of NHS was held constant at 10% (vol/vol), and the concentration of WN1 222-5 was varied as indicated, and (ii) supernatant TNF-α concentrations were measured by using the L929 cell cytotoxicity assay. The P values shown in parentheses below each horizontal axis indicate the statistical significance, as determined by two-way ANOVA, of differences in TNF-α concentration produced by the material specified for that axis. N.S., not significant (P > 0.05).