TABLE 1.

Inhibitory effects of peptides on cell uptake of LPS and LPS-induced cytokine secretion in the absence of serum

LPS-related activity	Significance of peptide-mediated inhibition (P)a
	Polymyxin B	SAEP-4	SAEP-2	Nonsense peptide
Uptake by CHO-CD14 cells	<0.0001	<0.0001	0.0387	0.2506
Uptake by PBMC	<0.0001	<0.0001	0.0294	0.3583
Uptake by CHO-NEO cells	<0.0001	<0.0001	0.0894	0.4376
IL-6 secretion by CHO-CD14 cells	0.0147	0.0013	0.0098	0.8283
IL-6 secretion by PBMC	<0.0001	<0.0001	0.0473	0.2202
IL-6 secretion by CHO-NEO cells	0.0064	0.0139	0.0684	0.6037
TNF-α secretion by PBMC	<0.0001	<0.0001	0.3872	0.4461

^aP value based upon one-way ANOVA.