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. 2022 Nov;11(11):1840–1851. doi: 10.21037/tp-22-529

Table 1. Univariate analysis of thrombosis group and no thrombosis group.

Variables Total (n=594) No thrombosis group (n=436) Thrombosis group (n=158) HR (95% CI) P
General information
   Age (months) 0.005
    <12 299 (50.3) 200 (66.9) 99 (33.1) 1.588 (1.150, 2.193)
    ≥12 295 (49.7) 236 (80.0) 59 (20.0) 1.0 (reference)
   Gender 0.747
    Male 317 (53.4) 233 (73.5) 84 (26.5) 0.950 (0.695, 1.298)
    Female 277 (46.6) 203 (73.3) 74 (26.7) 1.0 (reference)
   Blood purification 0.293
    Yes 108 (18.2) 72 (66.7) 36 (33.3) 1.222 (0.841, 1.777)
    No 486 (81.8) 364 (74.9) 122 (25.1) 1.0 (reference)
   On a ventilator 0.073
    Yes 402 (67.7) 282 (70.1) 120 (29.9) 1.397 (0.969, 2.015)
    No 192 (32.3) 154 (80.2) 38 (19.8) 1.0 (reference)
   Limb movement training 0.009
    Yes 248 (41.8) 198 (79.8) 50 (20.2) 0.639 (0.457, 0.894)
    No 346 (58.2) 238 (68.8) 108 (31.2) 1.0 (reference)
Related medications
   20% mannitol or glycerol fructose <0.001
    Yes 93 (15.7) 53 (57.0) 40 (43.0) 2.103 (1.467, 3.014)
    No 501 (84.3) 383 (76.4) 118 (23.6) 1.0 (reference)
   Furosemide 0.015
    Yes 347 (58.4) 237 (68.3) 110 (31.7) 1.527 (1.087, 2.144)
    No 247 (41.6) 199 (80.6) 48 (19.4) 1.0 (reference)
   Heparin sodium 0.097
    Yes 522 (87.9) 376 (72.0) 146 (28.0) 1.647 (0.913, 2.969)
    No 72 (12.1) 60 (83.3) 12 (16.7) 1.0 (reference)
   Hemostatic 0.295
    Yes 512 (86.2) 379 (74.0) 133 (26.0) 0.796 (0.519, 1.221)
    No 82 (13.8) 57 (69.5) 25 (30.5) 1.0 (reference)
   Hormones 0.928
    Yes 155 (26.1) 112 (72.3) 43 (27.7) 1.016 (0.715, 1.445)
    No 439 (73.9) 324 (73.8) 115 (26.2) 1.0 (reference)
Problems related to catheter insertion
   Catheter placing position
    Neck 472 (79.4) 359 (76.2) 113 (23.8) 0.778 (0.287, 2.111) 0.622
    Stock 108 (18.2) 67 (62.0) 41 (38.0) 1.403 (0.501, 3.923) 0.519
    Subclavian 14 (2.4) 10 (71.4) 4 (28.6) 1.0 (reference)
   Catheter placing personnel <0.001
    PICU personnel 193 (32.5) 108 (56.0) 85 (44.0) 2.900 (2.120, 3.966)
    Operating room anesthetist 401 (67.5) 328 (81.8) 73 (18.2) 1.0 (reference)
   Successful one-time catheterization 0.779
    Yes 591 (99.5) 434 (73.4) 157 (26.6) 0.754 (0.106, 5.388)
    No 3 (0.5) 2 (66.7) 1 (33.3) 1.0 (reference)
   Insertion length (cm) <0.001
    ≥9 157 (26.4) 95 (60.5) 62 (39.5) 2.088 (1.517, 2.875)
    <9 437 (73.6) 341 (78.0) 96 (22.0) 1.0 (reference)
Hemagglutination term before catheter insertion
   Prothrombin time 0.148
    >12 s 279 (47.0) 191 (68.5) 88 (31.5) 1.263 (0.921, 1.732)
    ≤12 s 315 (53.0) 245 (77.8) 70 (22.2) 1.0 (reference)
   Thrombin time 0.22
    >17 s 430 (72.4) 324 (75.3) 106 (24.7) 0.812 (0.583, 1.133)
    ≤17 s 164 (27.6) 112 (68.3) 52 (31.7) 1.0 (reference)
   Fibrinogen 0.041
    ≤1.7 g/L 211 (35.5) 141 (66.8) 70 (33.2) 0.720 (0.526, 0.986)
    >1.7 g/L 383 (64.5) 295 (77.0) 88 (23.0) 1.0 (reference)
   Activated partial prothrombin time 0.003
    >32 s 267 (44.9) 173 (64.8) 94 (35.2) 1.632 (1.185, 2.246)
    ≤32 s 327 (55.1) 263 (80.4) 64 (19.6) 1.0 (reference)
   D-dimer <0.001
    >1.5 g/L 271 (45.6) 174 (64.2) 97 (35.8) 1.872 (1.358, 2.581)
    ≤1.5 g/L 323 (54.4) 262 (81.1) 61 (18.9) 1.0 (reference)

Data are presented as n (%) if stated otherwise. HR, hazard ratio; CI, confidence interval; PICU, pediatric intensive care unit.