Table 2. Aspects for pre-and intraoperative evaluation of candidates for ROPRC.

Functional aspects prior to ROPRC	Oncological contraindications for ROPRC
Age	Bladder neck and trigonum involving bladder cancer
Performance status	Presence of preoperative hydronephrosis
Gynecological examination	Presence of CIS
History of abnormal vaginal bleeding	Clinical tumor stage ≥ cT3
Preoperative continence status	Suspected nodal-positive disease
Preoperative sexual function	Intraoperative positive urethral margins
Menopausal status	Intraoperative positive ureteral margins
Fertility goal	Family history for gynecological malignancies
Previous pelvic surgeries	Genetic predisposition for gynecological malignancies (BRCA1/2 mutations)

ROPRC, reproductive organ-preserving radical cystectomy; CIS, carcinoma in situ.