TABLE 2.

Results of the whole-brain analysis of the n-back data modeling APOE genotype group differences in activation during the n-back.

Regions	Maximam z-score	Peak X (MM)	Peak Y (MM)	Peak Z (MM)	Signal change ε 4 carriers (%)	Signal change non-carriers (%)	P-value
Left middle frontal gyrus1	3.56	−47	32	26	0.26 ± 0.50	0.62 ± 0.31	<0.01
Left precentral gyrus1	2.86	−61	5	27	0.08 ± 0.53	0.41 ± 0.40	<0.05
Left postcentral gyrus1	2.52	−63	4	27	0.13 ± 0.75	0.63 ± 0.78	<0.05
Left supramarginal gyrus1	3.51	−61	−46	33	0.01 ± 0.35	0.24 ± 0.30	<0.05
Left superior temporal gyrus1	2.98	−57	−33	11	−0.17 ± 0.24	0.07 ± 0.25	<0.01
Right putamen/insula2	3.45	28.5	6	−9.5	0.08 ± 0.16	0.27 ± 0.19	<0.001
Right lateral occipital cortex2	3.82	31	−70	37	0.16 ± 0.33	0.59 ± 0.28	<0.001
Left lateral occipital cortex2	2.70	−31	−63	33	0.19 ± 0.25	0.42 ± 0.32	<0.05
Left angular gyrus2	3.07	−60	−51	37	−0.04 ± 0.51	0.42 ± 0.32	<0.001
Left supramarginal gyrus2	2.99	−61	−46	33	−0.07 ± 0.30	0.23 ± 0.36	<0.01

Regions were created from 10 mm spheres generated around the peak activation from the voxel-wise and cluster thresholded maps from the whole-brain analysis. This analysis did not include covariates.

¹Regions significantly different during the 1-back condition (p < 0.05).

²Regions significantly different during the 2-back condition (p < 0.05).