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. 2022 Nov 30;42(48):9082–9096. doi: 10.1523/JNEUROSCI.1377-22.2022

Figure 1.

Figure 1.

Cognitive impairment in adult and aged mice 7 dpi. A, Adult (2 months of age) and aged (18 months of age) male C57BL/6 mice were subjected to midline fluid percussion injury (TBI) or left as uninjured CONs, and NOR/NOL memory was assessed (n = 6) 6 and 7 dpi. B, Self-righting time (in seconds) was determined immediately after TBI (n = 39). C–E, For NOR at 6 dpi, the total time spent exploring the objects (C), the percentage of time spent investigating the novel object (D), and the discrimination index for the novel object were determined (E). F–H, For NOL at 7 dpi, the total time spent exploring the objects (F), the percentage of time spent investigating the object in a novel location (G), and the discrimination index for the object in a novel location (H) were determined. Bars represent the mean ± SEM, and individual data points are provided. Means with different letters (e.g., a, b, c) indicate significant post hoc differences between groups (p < 0.05). Groups with the same letter or letters are not significantly different.