Figure 5.

Amplified cortical inflammation in aged mice that was associated with interferon signaling 7 dpi. Adult (2 months of age) and aged (18 months of age) male C57BL/6 mice were subjected to midline fluid percussion injury (TBI) or left as uninjured CONs. mRNA copy number was determined using a NanoString nCounter Neuropathology panel (n = 3), as in Figure 3. A, IPA of significant canonical pathways (z score) activated or inhibited by TBI in Aged-TBI mice compared with Adult-TBI mice. B, IPA of significant master regulators (z score) amplified by age in TBI mice.