Table 4.
Interaction between intellectual enrichment and genetic polymorphisms on cognitive function
| Model | DF | AIC | χ2 | P-value | P-value Bonferroni cor. |
|---|---|---|---|---|---|
| MSH3 | |||||
| Null model | 24 | 2931.8 | |||
| MSH3 by intellectual enrichment | 25 | 2933.1 | 0.7 | 0.404 | 1 |
| MSH3 by intellectual enrichment by visit | 26 | 2933.9 | 1.1 | 0.286 | 1 |
| FAN1 | |||||
| Null model | 24 | 2910.6 | |||
| FAN1 by intellectual enrichment | 25 | 2912.4 | 0.2 | 0.679 | 1 |
| FAN1 by intellectual enrichment by visit | 26 | 2914.4 | 0.0 | 0.833 | 1 |
| MAPT | |||||
| Null model | 24 | 2911.5 | |||
| MAPT by intellectual enrichment | 25 | 2913.5 | 0.0 | 0.895 | 1 |
| MAPT by intellectual enrichment by visit | 26 | 2915.5 | 0.0 | 0.894 | 1 |
| COMT | |||||
| Null model | 24 | 2910.2 | |||
| COMT by intellectual enrichment | 25 | 2912.2 | 0.0 | 0.960 | 1 |
| COMT by intellectual enrichment by visit | 26 | 2914.0 | 0.2 | 0.630 | 1 |
| BDNF | |||||
| Null model | 24 | 2907.6 | |||
| BDNF by intellectual enrichment | 25 | 2902.1 | 7.5 | 0.006 | 0.031 |
| BDNF by intellectual enrichment by visit | 26 | 2903.8 | 0.2 | 0.627 | 1 |
The null model included intellectual enrichment, the genetic polymorphism, age at baseline, site (three dummy variables), DBS at baseline with their interaction with visit, sex and use of antipsychotic medication. A quadratic term was also included for visit, as well as its interaction with DBS. P-values were corrected for five independent comparisons using Bonferroni correction.