Table 2. Columns are as follows.
, where α1 is the rate
of primary nucleation and α2 is the rate of secondary
nucleationa.
| mutant | λ | κ | κ/λ | longer fibrils? | saturated? |
|---|---|---|---|---|---|
| A2S | ∼ | ∼ | ∼ | Y | Y |
| A2T | ∼ | ∼ | ∼ | Y | Y |
| F4A | ↓ | ∼ | ↑ | Y | N |
| F4S | ↓ | ∼ | ↑ ↑ | ∼ | Y |
| V12A | ↓ ↓ | ↓ | ↑ ↑ | Y | N |
| V12S | ↓ ↓ | ↓ | ↑ ↑ | Y | N |
| Y10A | ↓ | ↓ | ∼ | Y | N |
| Y10F | ↓ | ∼ | ↑ ↑ | ∼ | Y |
| Y10S | ↓ | ↓ | ∼ | Y | Y |
Fibril length trends are in the
penultimate column, and mean fibril length is known to equal
. The final column refers to the saturation
of secondary nucleation. Double arrows mean changes of more than an
order of magnitude. Tildes mean changes of less than a factor of 2.