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. 2022 Nov 21;13(23):3477–3487. doi: 10.1021/acschemneuro.2c00504

Table 2. Columns are as follows. Inline graphic, where α1 is the rate of primary nucleation and α2 is the rate of secondary nucleationa.

mutant λ κ κ/λ longer fibrils? saturated?
A2S Y Y
A2T Y Y
F4A Y N
F4S ↑ ↑ Y
V12A ↓ ↓ ↑ ↑ Y N
V12S ↓ ↓ ↑ ↑ Y N
Y10A Y N
Y10F ↑ ↑ Y
Y10S Y Y
a

Fibril length trends are in the penultimate column, and mean fibril length is known to equal Inline graphic. The final column refers to the saturation of secondary nucleation. Double arrows mean changes of more than an order of magnitude. Tildes mean changes of less than a factor of 2.