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. Author manuscript; available in PMC: 2023 Apr 18.
Published in final edited form as: Sci Signal. 2022 Oct 18;15(756):eabn4948. doi: 10.1126/scisignal.abn4948

Figure 2: Fusobacterium infection elicits secretion of specific cytokines from host cells.

Figure 2:

(A) Heat maps depicting the percent change in cytokine secretion from BxPC3 and Panc1 cells in response to E. coli, Fnn, or Fnn Δfap2 infection in comparison to non-infected cells using the Human XL Cytokine Array. # denotes increases in secretion of GM-CSF, CXCL1, IL-8, and MIP-3α. (B) Quantitative analysis of select cytokine secretion from BxPC3 and Panc1 cells upon infection with E. coli, Fnn, or Fnn Δfap2, using ELISA. (C) Quantitative analysis of select cytokine secretion from BxPC3 and Panc1 cells upon infection with other F. nucleatum strains: animalis (Fna), polymorphum (Fnp), and vincentii (Fnv). Data in (B and C) are means ± SEM from N = 3 independent experiments per condition; comparisons by ordinary one-way ANOVA followed by Tukey’s multiple comparisons test (B) or Dunnett’s multiple comparisons test (C): * P≤0.05, ** P≤0.01, *** P≤0.001, and **** P≤0.0001; ns, not significant.