Supplementary Table 2.

Adjusted odds ratio in patients with 1, 2, or 3 units of autologous blood removed compared to patients who had no autologous blood removed (Control group). Regressions used the unadjusted intravenous fluids and cardiopulmonary bypass volume. Any transfusion is sum of intraoperative and postoperative. KDIGO – Kidney disease improving global outcome, within the first 3 postoperative days. Undef – undefined.

Number of units of blood removed
	1 unit			2 units			3 units
Factor	Odds ratio 95% CI		p-value	Odds ratio 95% CI		p-value	Odds ratio 95% CI		p-value
Calcium administration	2.26	(0.61, 8.41)	0.223	2.28	(0.88, 5.95)	0.091	undef	(0, oo)	0.986
Any vasopressor infusion	1.69	(0.90, 3.15)	0.101	1.62	(1.01, 2.59)	0.044	1.87	(0.97, 3.61)	0.061
Ephedrine administration	1.14	(0.81,1.60)	0.461	1.73	(1.32,2.26)	<0.001	1.90	(1.37, 2.64)	<0.001
Intraoperative transfusion
Red cell	0.35	(0.25, 0.50)	<0.001	0.24	(0.17, 0.32)	<0.001	0.09	(0.06, 0.13)	<0.001
Plasma	0.50	(0.36, 0.70)	<0.001	0.37	(0.28, 0.48)	<0.001	0.09	(0.06, 0.13)	<0.001
Platelet	0.48	(0.35, 0.66)	0.001	0.39	(0.29, 0.51)	<0.001	0.10	(0.07, 0.16)	<0.001
Cryoprecipitate	0.58	(0.34, 1.01)	0.053	0.81	(0.56,1.16)	0.248	0.22	(0.13, 0.37)	<0.001
Any transfusions
Red cells (units)	0.41	(0.28, 0.60)	<0.001	0.25	(0.18, 0.34)	<0.001	0.09	(0.06, 0.15)	<0.001
Plasma (units)	0.48	(0.34, 0.67)	<0.001	0.36	(0.26, 0.48)	<0.001	0.08	(0.05, 0.12)	<0.001
Platelets (units)	0.43	(0.31, 0.60)	<0.001	0.39	(0.29, 0.52)	<0.001	0.11	(0.07, 0.17)	<0.001
Cryoprecipitate (units)	0.47	(0.26, 0.88)	0.017	0.81	(0.53, 1.23)	0.315	0.18	(0.09, 0.33)	<0.001
KDIGO stage 1 or worse	1.15	(0.85,1.55)	0.378	0.98	(0.76, 1.27)	0.888	0.91	(0.64,1.28)	0.572
KDIGO stage 2 or worse	0.64	(0.33,1.23)	0.181	0.85	(0.51,1.41)	0.516	0.71	(0.34,1.48)	0.361