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. 2022 Dec 8;20:472. doi: 10.1186/s12916-022-02649-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Tumor response. A Waterfall plot of tumor size change from baseline to maximum percentage in each patient as per RECIST version 1.1. B Longitudinal change in tumor size from baseline. C Time to response and duration of response. D Duration of response for patients with advanced ESCC. CR, complete response; PR, partial response; PD, progressive disease; SD, stable disease; NE, not evaluable; ESCC, esophageal squamous cell carcinoma. Asterisk symbol (*) indicates the following: CR was confirmed with the disappearance of all target lesions and any pathological lymph nodes (whether target or non-target) must have a reduction in short axis to < 10 mm