Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 8;15:173. doi: 10.1186/s13045-022-01391-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — The procedures after osimertinib resistance. Before osimertinib treatment, patients should be examined via tissue biopsy and/or liquid biopsy to confirm whether EGFR mutations exist. Liquid biopsy can be used as a noninvasive and practical method for dynamic monitoring to evaluate genomic status in the period of osimertinib treatment. When patients progress on osimertinib, tissue biopsy and/or liquid biopsy should be conducted to determine the mechanisms of resistance to osimertinib to guide treatment. A corresponding treatment regimen will be applied to treat patients if effective approaches currently exist; in the case of a lack of valid targets, preclinical studies and clinical trials are warranted to be taken into consideration for the acquisition of valuable evidence to further explore viable therapeutic strategies