Table 3.
Adverse event of TTM among the study population according to targeted temperature
| All patients | Original cohort | Crude analysis OR (95% CI) |
Multivariable analysis AOR (95% CI)a |
||
|---|---|---|---|---|---|
| n-TTM | h-TTM | ||||
| N = 617 | N = 151 | N = 466 | |||
| Any adverse event of TTM | 124 (20.1) | 29 (19.2) | 95 (20.4) | 1.08 (0.68–1.78) | 1.08 (0.63–1.82) |
| Bleeding | 70 (11.4) | 12 (7.9) | 58 (12.4) | 1.65 (0.86–3.16) | 1.47 (0.69–3.10) |
| Arrhythmia | 31 (5.2) | 7 (4.6) | 24 (5.2) | 1.12 (0.47–2.65) | 1.28 (0.50–3.31) |
| Hypotension | 76 (12.3) | 20 (13.2) | 56 (12.0) | 0.90 (0.52–1.55) | 1.04 (0.55–1.95) |
| Infection | 24 (3.9) | 2 (1.3) | 22 (4.7) | 3.69 (0.86–15.9) | 6.09 (0.79–46.8) |
| Other | 8 (1.3) | 5 (3.3) | 3 (0.6) | 0.19 (0.04–0.80) | 0.08 (0.01–0.67) |
Shown data are calculated for patients for whom data were available (n = 617/890)
Values are expressed numbers (percentages) unless indicated otherwise
TTM targeted temperature management, n-TTM normothermic TTM, h-TTM hypothermic TTM, OR odds ratio, AOR adjusted odds ratio, CI confidence interval
aShown is the AOR from the multivariable logistic regression analysis adjusted for age, sex, cause of arrest, bystander witness, bystander CPR, use of public-access AEDs, prehospital epinephrine administration, prehospital advanced airway management, time from EMS call to contact with the patients, time from EMS contact with the patients to hospital arrival, type of centre, the annual volume of ECMO used for OHCA at each centre, success of PCI, timing of ECMO start, time from hospital arrival to induction of ECMO, and TTM induction time