Table 3.

Subgroup analyses for the association between FBG and RPL

					Test for subgroup differences
Subgroup	No. of comparisons	MD (95%CI)	I2 (%)	P-value for heterogeneity	Chi2	P	I2 (%)
Region
Asia	7	2.48 [0.33, 4.63]	91	< 0.00001	6.31	0.18	36.6
Africa	2	11.63 [-7.58, 30.84]	96	< 0.00001
Europe	2	-1.74 [-9.36, 5.88]	88	0.003
America	2	-1.08 [-4.24, 2.07]	34	0.22
Middle East	6	3.49 [-0.15, 7.13]	74	0.002
Definition of RPL
>  = 2	10	3.82 [1.17, 6.47]	94	< 0.00001	2.89	0.09	65.4
>  = 3	9	1.27 [0.00, 2.54]	16	0.30
Matched confounders
No	8	1.09 [-0.84, 3.02]	87	< 0.00001	2.64	0.10	62.2
Yes	11	4.20 [0.98, 7.41]	89	< 0.00001
Measurement timing
During pregnancy	3	2.12 [-2.50, 6.73]	88	0.0002	0.06	0.80	0
Not during pregnancy	16	2.75 [0.80, 4.70]	88	< 0.00001
Exclusion of known factors
Yes	14	2.66 [0.54, 4.77]	9	< 0.00001	0.02	0.89	0
No	5	2.88 [0.72, 5.03]	62	0.03