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. Author manuscript; available in PMC: 2022 Dec 9.
Published in final edited form as: Mol Carcinog. 2013 Sep 5;54(2):134–147. doi: 10.1002/mc.22081

Figure 1.

Figure 1.

A schematic of human MCS5A1 and the rat genomic region of Mcs5a1 used to make 4.2 kb Fbxo10 luciferase reporter constructs. (A) The human MCS5A1 locus is a 5.7 kb region of human chromosome 9 that contains four breast cancer risk associated polymorphisms (rs7042509, rs6476643, rs10758441, and indel138–9899, marked with black circles). (B) The rat Mcs5a1 locus is a 32 kb region of rat chromosome 5 that contains segments hypothesized to be 5′-Fbxo10 regulatory regions. Relative locations of genetic variants between mammary cancer susceptible WF and resistant WKY alleles are marked with black circles. Asterisks represent potential TRE (predicted AP1 binding sites). The lengths of all reporter constructs are shown and more detailed information regarding these variants is available in Table 1. Human and rat FBXO10/Fbxo10 conserved 5′-UTRs and an intronic segment are shown for reference. The human/rat conserved CpG islands contain FBXO10/Fbxo10 T cell preferred transcription start sites (TSS).