Table 2.
The stability analysis of mutations by different servers and software
| Mutation (kcal/mol) |
ΔΔG DynaMut |
ΔΔG ENCoM |
ΔΔG mCSM |
ΔΔG SDM |
ΔΔG DUET |
ΔΔG FoldX |
|---|---|---|---|---|---|---|
| KIF21A F355S | − 1.974 | − 0.998 | − 1.709 | − 1.400 | − 1.717 | 3.006 |
| Destabilizing | Destabilizing | Destabilizing | Destabilizing | Destabilizing | Destabilizing | |
| CHN1 H217R | − 0.395 | 0.021 | − 1.270 | − 0.390 | − 1.108 | 0.204 |
| Destabilizing | Destabilizing | Destabilizing | Destabilizing | Destabilizing | Stabilizing | |
| TUBB3 S78T | − 0.066 | − 0.063 | − 0.206 | 0.090 | 0.227 | − 0.4751 |
| Destabilizing | Destabilizing | Destabilizing | Stabilizing | Stabilizing | Stabilizing |