Table 3.

Hazard Ratios and 95% Confidence Interval for CHD and CVD According to Continuous CAC Density and CAC Density Quartile

	DM (n = 668)	MetS (n = 1122)	Neither DM/MetS (n = 2028)
CHD
N (%) of events	161 (24.1%)	203 (18.1%)	276 (13.6%)
Per 1 SD of CAC density	0.91 (0.72–1.16)	0.70 (0.56–0.87)†	0.79 (0.66–0.95)*
CAC density Q2 versus Q1	0.79 (0.44–1.41)	0.88 (0.53–1.46)	0.93 (0.60–1.44)
CAC density Q3 versus Q1	0.79 (0.43–1.46)	0.67 (0.38–1.20)	0.56 (0.35–0.92)*
CAC density Q4 versus Q1	0.89 (0.47–1.67)	0.50 (0.28–0.91)*	0.59 (0.36–0.97)*
CVD
N (%) of events	248 (37.1%)	308 (27.5%)	433 (21.4%)
Per 1 SD of CAC Density	0.77 (0.64–0.94)†	0.83 (0.70–0.99)*	0.82 (0.71–0.95)†
CAC density Q2 versus Q1	0.71 (0.45–1.10)	1.04 (0.70–1.56)	0.81 (0.58–1.12)
CAC density Q3 versus Q1	0.62 (0.38-1.00)*	1.04 (0.66–1.64)	0.53 (0.37–0.78)†
CAC density Q4 versus Q1	0.54 (0.32–0.89)*	0.67 (0.41–1.08)	0.59 (0.41–0.86)†

Models were adjusted for 10-year ASCVD risk, race/ethnicity, education, BMI, statin therapy and ln(Volume)

ASCVD  Atherosclerotic cardiovascular disease, BMI  Body mass index, CAC Coronary artery calcium, CHD Coronary heart disease, CVD  Cardiovascular disease, DM  diabetes mellitus, MetS  metabolic syndrome

*p < 0.05, †p < 0.01