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. 2022 Dec 9;26:76. doi: 10.1186/s40824-022-00320-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Illustration for the working principle of the designed NIR ratiometric fluorescent probe HBAE for the determination of BACE1 in neurons and mouse brain tissue slice. A the 3D docked conformation of the BACE1 and HBAE of the X-ray structure of BACE1. B the 2D docked conformation of the BACE1 and HBAE of the X-ray structure of BACE1 (PDB entry 5I3Y)