Table 3.
Plasma and CSF concentrations of NfL between groups
| n | P-log-NfL, pg/ml, mean (SD) | n | CSF-log-NfL, pg/ml, mean (SD) | |
|---|---|---|---|---|
| SLE patients | 72 | 0.84 (0.17) | 32 | 2.58 (0.30) |
| Healthy controls | 26 | 0.71 (0.17) | 0 | N/A |
| p value | 0.003 | N/A | ||
| NPSLE (SLICC A model) | 16 | 0.87 (0.13) | 8 | 2.73 (0.34) |
| Non-NPSLE (SLICC A model) | 56 | 0.83 (0.18) | 24 | 2.53 (0.27) |
| p value | 0.40 | 0.11 | ||
| NPSLE (SLICC B model) | 23 | 0.87 (0.14) | 12 | 2.65 (0.30) |
| Non-NPSLE (SLICC B model) | 49 | 0.83 (0.18) | 20 | 2.54 (0.30) |
| p value | 0.33 | 0.30 | ||
| NPSLE (ACR model) | 44 | 0.86 (0.16) | 21 | 2.62 (0.32) |
| Non-NPSLE (ACR model) | 28 | 0.81 (0.17) | 11 | 2.51 (0.28) |
| p value | 0.17 | 0.32 |
n Number of subjects, P Plasma, Log Log-transformed value, NfL Neurofilament Light, SD Standard deviation, CSF Cerebrospinal fluid, N/A not applicable, SLICC Systemic Lupus International Collaborating Clinics, ACR American College of Rheumatology