Table 6.
Associations between plasma NfL and CNS-VS test results
| BRIEF-CORE Clinical Domain | Valid tests | r | p-value | Domain impairmenta, n (%) |
|---|---|---|---|---|
| Multiple Test Domains | ||||
| Neurocognitive Index | 67 | − 0.026 | 0.83 | 5 (8%) |
| Composite Memory | 70 | − 0.042 | 0.73 | 9 (13%) |
| Complex Attention | 67 | −0.044b | 0.72 | 8 (12%) |
| Cognitive Flexibility | 68 | 0.019 | 0.88 | 8 (12%) |
| Single Test Domains | ||||
| Psychomotor Speed | 70 | −0.19 | 0.11 | 4 (6%) |
| Reaction Time | 69 | −0.077 | 0.53 | 16 (23%) |
| Visual Memory | 70 | −0.002 | 0.99 | 9 (13%) |
| Processing Speed | 70 | −0.065 | 0.60 | 5 (7%) |
| Executive Function | 69 | −0.016 | 0.90 | 8 (12%) |
| Simple Attention | 38 | −0.41b | 0.010 | 4 (11%) |
| Motor Speed | 39 | −0.17 | 0.30 | 2 (5%) |
| Verbal Memory | 70 | −0.073 | 0.55 | 8 (11%) |
r Pearson’s correlation coefficient, NfL Neurofilament Light, n Number of subjects, % Proportion of subjects, CNS-VS CNS-Vital Signs
a“Domain impairment” defined by an individual score below minus 2 standard deviations
bSpearman’s correlation coefficient