Table 3.
Generalized linear model analysis of DNA methylation levels of three CpG sites in promoter of the CYP2E1 gene
| Group | Parameters | Site 1 | Site 2 | Site 3 | Average |
|---|---|---|---|---|---|
| TD | Mean ± SD | 11.1 ± 10.6 | 8.7 ± 10.8 | 6.6 ± 9.6 | 8.8 ± 10.0 |
| NTD | 16.4 ± 12.3 | 14.3 ± 12.5 | 12.7 ± 11.0 | 14.5 ± 11.9 | |
| HC | 15.9 ± 11.3 | 15.5 ± 12.1 | 13.8 ± 10.9 | 15.1 ± 11.3 | |
| Levene’s F Statistics | F | 0.045 | 0.316 | 0.559 | 0.199 |
| p | 0.956 | 0.730 | 0.574 | 0.920 | |
| TD vs. NTD vs. HC | F | 2.64 | 3.79 | 6.23 | 3.93 |
| p | 0.0762 | 0.0258 | 0.0026* | 0.0227 | |
| TD vs. HC | t | − 1.89 | − 2.58 | − 3.33 | − 2.57 |
| p | 0.0615 | 0.0114* | 0.0012* | 0.0115* | |
| NTD vs. HC | t | 0.19 | − 0.45 | − 0.59 | − 0.33 |
| p | 0.8531 | 0.0657 | 0.5561 | 0.7442 | |
| TD vs. NTD | t | − 2.08 | − 2.13 | − 2.74 | − 2.25 |
| p | 0.0404 | 0.0355 | 0.0072* | 0.0268 |
Abbreviations: TD, tardive dyskinesia; NTD, without tardive dyskinesia; HC, health controls; F value is based on the generalized linear model for comparing three groups; t value is based on the generalized linear model for comparing two groups. * p < 0.0167 based on Bonferroni correction