Table 1.
Characteristics of the included studies
| Study | Operative period | Country | Study type | Study population | Cut-off of FFR | Follow-up (mo) | Type of surgery | Statistical methods | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Total | FFR | CAG | ||||||||
| Fournier et al. [13] (2018) | 2006–2010 | Belgium | NRS | 396 | 198 | 198 | 0.8 | 86 | Isolated CABG | PSM |
| Moscona et al. [14] (2018) | 2014–2016 | USA | NRS | 109 | 14 | 95 | 0.8 | 18 | Isolated CABG | UV |
| Thuesen et al. [15] (2018) | 2014–2016 | Denmark | RCT | 97 | 49 | 48 | 0.8 | 6 | Isolated CABG | RCT |
| Toth et al. [16] (2019) | 2012–2016 | Europe | RCT | 172 | 88 | 84 | 0.8 | 12 | Isolated CABG | RCT |
| Rioufol et al. [17] (2021) | - | France | RCTa) | 109 | 54 | 55 | 0.8 | 12 | Isolated CABG | RCTa) |
| Di Gioia et al. [18] (2016) | 2002–2010 | Belgium | NRS | 144 | 41 | 103 | 0.8 | 60 | CABG+AVR | PSMb) |
FFR, fractional flow reserve; CAG, coronary angiography; NRS, non-randomized study; CABG, coronary artery bypass graft surgery; PSM, propensity score matching; UV, univariate analysis; RCT, randomized controlled trial; AVR, aortic valve replacement.
a)The study design was an RCT, but the enrolled patients underwent either a percutaneous intervention or CABG. b)The study design was PSM, but the enrolled patients underwent various treatments, and data from patients who underwent CABG+AVR were analyzed.