Figure 1.

Correlation Between Established Immunogenomic Factors and Immune-Related Adverse Events for Anti–PD-1 Therapy Across Cancer Types (A), Evaluation of immunogenomic correlates of immune-related adverse events (irAEs) for immunotherapy to block the PD-1 pathway across cancer types. The horizontal axis denotes the 41 established immunogenomic factors, and the vertical axis denotes Pearson correlation coefficient (R). Circles are filled with distinct colors as per statistical significance of corresponding factors. (B, C), Correlation of dendritic cells abundance (DC) (B) and log(tumor mutational burden [TMB]) (C) with the reporting odds ratio of any irAE across 21 cancer types which are color coded. The dashed line depicts the linear fit. FDR, false discovery rate; NS, not significant.