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. Author manuscript; available in PMC: 2023 Feb 9.
Published in final edited form as: J Med Chem. 2022 May 24;65(11):7656–7681. doi: 10.1021/acs.jmedchem.1c02171

Scheme 5. Synthesis of Pyrazole Analogues 38, 40, and 42a.

Scheme 5.

a(a) Pyrazole boronic acid, NaHCO3, DMF, 105 °C, 24 h, 46–53%; (b) (i) NaH, THF, 0 °C, 0.5 h; (ii) tert-butyl(3-bromopropyl)carbamate, THF 0–25 °C, 18 h, 16–77%; (c) 4 M HCl/dioxane, DCM, rt, 2 h, 78–89%.