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. Author manuscript; available in PMC: 2023 Feb 9.
Published in final edited form as: J Med Chem. 2022 May 24;65(11):7656–7681. doi: 10.1021/acs.jmedchem.1c02171

Scheme 11. Synthesis of Amide Derivatives 72a–ba.

Scheme 11.

a(a) Carboxylic acid, DIEA, HCTU, DCM, rt, 18 h, 84–89%; (b) NH2OH·HCl, EtOH, 78 °C, 2 h, 88–95%; (c) N-Boc-GABA, DIEA, HCTU, DMF, 100 °C, 6 h, 22–77%; (d) 4 M HCl/dioxane, DCM, rt, 2 h, 68–80%.