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. Author manuscript; available in PMC: 2023 Feb 9.
Published in final edited form as: J Med Chem. 2022 May 24;65(11):7656–7681. doi: 10.1021/acs.jmedchem.1c02171

Scheme 2. Synthesis of Diamine Analogues 19a–d and 21a.

Scheme 2.

a(a) Diprotected amino acid, DIEA, HCTU, THF, 80 °C, 4 h, 40–74%; (b) morpholine, DMF, rt, 18 h, 34–85%; (c) 4 M HCl/dioxane, DCM, rt, 2 h, 37–85%; (d) Ac2O, TEA, neat, rt, 0.5 h, 48%.