Table 2.

Subgroup analysis of randomized controlled trials

Nature of RCTS	Subgroups	Total RCTs	Safety Statistics		Type of Study
			Present	Absent	IIS	PISS
IIS/PISS	IIS	299	183	116
	PISS	324	92	232
Phase of trial	Phase 1	8	0	8	0	8
	Phase 1/2	4	0	4	1	3
	Phase 2	60	20	40	30	30
	Phase 2/3	14	5	9	10	4
	Phase 3	368	148	220	138	230
	Phase 4	48	33	15	30	18
	Not mentioned	121	69	52	90	31
Intervention	Surgery	63	38	25	44	19
	Pharma	403	150	253	153	250
	Vaccine	22	8	14	7	15
	Device	23	14	9	13	10
	Radiotherapy	2	1	1	1	1
	Others	93	53	40	6	87
	Combination therapy	17	11	6	8	9
Therapeutic Area	Cardiovascular	172	120	52	83	89
	Oncology	101	20	81	34	68
	Infectious Disease	94	35	59	51	43
	Respiratory	52	21	31	27	25
	Metabolic	37	13	24	19	18
	Neurology	34	15	19	18	16
	Immunology	32	5	27	7	25
	Haematology	23	7	16	8	15
	Nephrology	15	9	6	10	5
	Musculoskeletal	14	3	11	9	5
	Gastrointestinal	10	4	6	4	6
	Others	39	23	16	28	10