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. 2022 Dec 5;17:6007–6029. doi: 10.2147/IJN.S386585

Table 3.

The Mechanism Underlying the Diabetic Wound Healing of Nanoparticles

Mechanisms Classification of Nanoparticles Delivery Carriers References
Promotion of angiogenesis GFs NaCMCh/PLGA NPs, [10,24–26]
Col-HA-GN nanofibrous membrane, AlgSulf/PCL NPs, ELPs, [27–29]
Genetic molecule PLGA NPs, PAM-RG4 [38,39]
Exosomes FEP dressing, MC-CS HG [33,37]
Small molecule compounds EV NPs, [67]
Metal NPs SNPECHG, 11-MTA/VEGF, Biopolymer fibers, BGNs, PABC HG [82,95,96,98,99]
Antibacterial action Small molecule compounds Chitosan, PLGA nanoparticles [62,66]
Metal NPs EPL-g-butyl, FKDP, CS/Ca-AlgNP, CS-PEG, antifouling HG, VAN-AgNCs, HA, CS-HA, CNCs, LL37, BG-HG, CA-HG [19,75,76,79–81,87,88,90,91,93,100,108]
Anti-inflammatory and antioxidation Small molecule compounds CS NPs, NP/HG, GMs/HG, PLGA nanosuspensions, NE, KCNE, CS, Liposomal nanoparticles, HG, SA wafers, HA-pep-PAMAM, ointment [50–54,56–58,63,68–71]
Genetic molecule BC-HCP, β-CD-[D3]7, LPP [22,44,45]
Metal NPs AuNPs, BG/GelMA HG, GelMA HG patches, PHBV film, CNPs, Nanosilk solutions, Zwitterionic cryogel, [92,100,102–104,106,107]