Table 2.

Performance, reproducibility and reliability of individual radiomic features capable of differentiating malignant from benign pulmonary nodules

Radiomic features	AUC (95% CI)	p-values	R1 CCC (95% CI)	R2 CCC (95% CI)	R12 CCC (95% CI)
Correlation maximum DWI B0	0.780 (0.672, 0.887)	0.004	0.998 (0.998, 0.999)	0.918 (0.873, 0.947)	0.919 (0.876, 0.948)
Correlation maximum DWI B50	0.818 (0.718, 0.917)	<0.001	0.999 (0.998, 0.999)	0.925 (0.883, 0.952)	0.842 (0.763, 0.897)
Correlation mean DWI B0	0.760 (0.645, 0.876)	0.001	0.999 (0.998, 0.999)	0.979 (0.967, 0.987)	0.946 (0.915, 0.966)
Correlation mean DWI B50	0.779 (0.663, 0.895)	<0.001	0.997 (0.996, 0.998)	0.980 (0.969, 0.988)	0.944 (0.913, 0.965)
Correlation median DWI B0	0.753 (0.636, 0.869)	0.001	0.999 (0.998, 0.999)	0.981 (0.970, 0.988)	0.932 (0.894, 0.957)
Correlation median DWI B50	0.764 (0.645, 0.883)	<0.001	0.998 (0.997, 0.999)	0.984 (0.974, 0.990)	0.941 (0.908, 0.963)
Correlation 75th percentile DWI B0	0.766 (0.651, 0.881)	0.001	0.999 (0.999, 0.999)	0.979 (0.968, 0.987)	0.959 (0.936, 0.974)
Correlation 75th percentile DWI B50	0.794 (0.682, 0.907)	<0.001	0.996 (0.994, 0.998)	0.963 (0.942, 0.976)	0.880 (0.816, 0.923)
Correlation skew DWIB0	0.735 (0.616, 0.855)	0.004	0.995 (0.992, 0.997)	0.897 (0.845, 0.933)	0.866 (0.795, 0.914)
Energy SD DWI B0	0.731 (0.609, 0.852)	0.015	0.997 (0.995, 0.998)	0.926 (0.884, 0.953)	0.822 (0.734, 0.883)
Homogeneity SD DWI B0	0.733 (0.616, 0.851)	0.003	0.997 (0.995, 0.998)	0.890 (0.830, 0.929)	0.842 (0.765, 0.896)

AUC = area under the receiver operating characteristic curve; CCC = Lin’s concordance correlation coefficient; CI = confidence interval; DWI = diffusion-weighted imaging; R1 = Reader 1 intrareader; R2 = Reader 2 intrareader; R12 = interreader-reader.