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DSC profile overlay of a representative antibody in WT and TM-YTE format. Thermal stability of a representative antibody in WT and TM-YTE format was assessed by DSC. Introduction of TM-YTE modifications results in decreased thermal stability of CH2, as seen by the lower temperature for the first (Tm1) melting peak. A DSC graph plotting the melting temps of Ab 4 in WT format versus TM-YTE format. The Tm1 peak is ~58°C for the TM-YTE format and ~72°C for the WT format.
