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. 2022 Dec 8;15(1):2152526. doi: 10.1080/19420862.2022.2152526

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — SARS-CoV-2 TM-YTE antibodies do not show Nonspecific Binding (NSB) in BVP ELISA and HEK binding assay. (a+b) The TM-YTE antibody panel was tested for NSB in a BVP ELISA: (a) BVP assay score and (b) BSA or plate binding of the TM-YTE antibody panel. (c) HEK binding assay. NIP228 is a negative control antibody that exhibits low NSB in these assays, and NSB mAb is a positive control antibody that exhibits high NSB in these assays. Assays were repeated three times, representative graphs are shown. Bars represent standard deviations. (a) A bar graph plotting the BVP binding assay score of Ab 1–8 compared to positive control (“NSB mAb”) and negative control (NIP228) antibodies. Assay score for Ab 1–8 is similar to negative control. (b) A bar graph plotting the plate/BSA binding OD (450 nm) of Ab 1–8 compared to positive (“NSB mAb”) and negative control (NIP228) antibodies. The OD of Ab 1–8 is similar to negative control. (c) A line graph plotting the HEK binding assay fluorescent signal versus antibody concentration for Ab 1–8 compared to positive (“NSB mAb”) and negative control (NIP228) antibodies. The fluorescent signal of Ab 1–8 is similar to negative control.