Table 1.
Melting temperature of SARS-COV-2 antibody domains by DSC. Thermal stability was assessed by DSC. All antibodies, unless otherwise specified, are in the TM-YTE format and have a lower Tm1 than the corresponding antibody in the WT format. Tm2 varies among the antibody panel.
| Name | Tm 1 – CH2 (°C) | Tm 2 – Fab (°C) |
|---|---|---|
| Antibody 1 | 58.3 | 83.0 |
| Antibody 2 | 58.2 | 69.5 |
| Antibody 3 | 58.2 | 81.9 |
| Antibody 4 | 58.2 | 82.9 |
| Antibody 5 | 58.1 | 76.0 |
| Antibody 6 | 58.4 | 66.8 |
| Antibody 7 | 57.9 | 74.6 |
| Antibody 8 | 58.2 | 66.0 |
| Antibody 4 WT | 72.0 | 83.2 |
| Antibody 7 WT | 75.2 | |