Table 2.
The clinical features and prognosis of pregnancy-related ON in different groups.
| Clinical feature | All | ION | AQP4-ON | MOG-ON | P1 value | P2 value | P3 value |
|---|---|---|---|---|---|---|---|
| Number of patients, n | 54 | 21 | 27 | 6 | |||
| Bilateral attack, n (%) | 23 (42.6%) | 7 (33.3) | 13 (48.1) | 3 (50) | 0.382 | 0.638 | 1.000 |
| Ocular pain | 48/54 (88.9) | 18/21 (85.7) | 24/27 (88.9) | 6/6 (100.0) | 1.000 | 1.000 | 1.000 |
| Disk edema | 25/54 (46.3) | 13/21 (61.9) | 7/27 (25.9) | 5/6 (83.3) | 0.019 | 0.628 | 0.016 |
| Abnormal autoimmune antibodies, n (%) | 10(18.5) | 0 | 9 (33.3%) | 1 (16.7%) | 0.003 | 0.222 | 0.640 |
| HLA-B27, n (%) | 1 (1.9) | 0 | 1 (3.7%) | 0 | / | / | / |
| VA at onset, eyes, n | 77 | 28 | 40 | 9 | |||
| ≤ 0.1 | 64 (83.1) | 19 (67.9) | 37 (92.5) | 8 (88.9) | 0.021 | 0.393 | 0.569 |
| < 0.5–> 0.1 | 8 (10.4) | 6 (21.4) | 2 (5.0) | 0 | 0.057 | 0.302 | 1.000 |
| ≥ 0.5 | 5 (6.5) | 3 (10.7) | 1 (2.5) | 1 (11.1) | 0.298 | 1.000 | 0.337 |
| VA at recovery, eyes, n | 77 | 28 | 40 | 9 | |||
| ≤ 0.1 | 20 (26.0) | 3 (10.7) | 17 (42.5) | 0 | 0.006 | 0.562 | 0.019 |
| < 0.5–> 0.1 | 10 (13.0) | 1 (3.6) | 9 (22.5) | 0 | 0.039 | 1.000 | 0.179 |
| ≥ 0.5 | 47 (61.0) | 24 (85.7) | 14 (35.0) | 9 (100.0) | 0.000 | 0.554 | 0.000 |
| RNFL thickness, eyes, n | 54 | 19 | 30 | 5 | |||
| Average thickness (mean ± SD) | 70.20 ± 16.63 | 79.0 ± 18.69 | 62.20 ± 10.82 | 84.80 ± 11.37 | 0.001 | 0.518 | 0.000 |
| Superior quadrant (mean ± SD) | 81.07 ± 28.25 | 92.47 ± 34.02 | 71.27 ± 21.54 | 96.6 ± 19.09 | 0.022 | 0.799 | 0.019 |
| Nasal quadrant (mean ± SD) | 57.65 ± 10.31 | 61.53 ± 11.47 | 54.03 ± 6.49 | 64.6 ± 16.76 | 0.050 | 0.632 | 0.233 |
| Inferior quadrant (mean ± SD) | 87.22 ± 29.29 | 104.84 ± 29.77 | 72.13± 21.09 | 110.8 ± 16.63 | 0.000 | 0.674 | 0.000 |
| Temporal quadrant (mean ± SD) | 50.80 ± 15.16 | 55.16 ± 18.47 | 45.40 ± 7.69 | 66.6 ± 21.40 | 0.040 | 0.244 | 0.091 |
| T2 lesions in orbit MRI | 49 (90.7) | 19 (90.5) | 24 (88.9) | 6 (100) | 1.000 | 1.000 | 0.239 |
VA, visual acuity; RNFL, retinal nerve fiber layer.
Numbers in bold indicate p < 0.05.