Table 1.
The applications of stem cells in the treatment of POF.
| Type of stem cell | Function | Authors name | Year | References |
|---|---|---|---|---|
| ESCs | Repair endometrial damage | Wang et al. | 2019 | (109) |
| MSCs | Produce cytokines, regulate inflammation | Trounson et al. | 2017 | (110) |
| Secret exosomes to regulate the PI3K/Akt/mTOR pathway, promote ovarian angiogenesis, induce apoptosis of cells | Qu et al. | 2022 | (111) | |
| BMSCs | Restore function and structure of follicles and increase estrogen and vascular endothelial growth factor levels | Somia et al. | 2013 | (112) |
| Restore ovarian hormone production and reactivate folliculogenesis | Mohamed et al. | 2018 | (113) | |
| hMensSCs | Increase ovarian weight, normal follicles number, AMH and estrogen level | Liu et al. | 2014 | (114) |
| hUCMSCs | Increase ovarian reserve function | Li et al. | 2017 | (115) |
| Increase the activity of the PI3K/Akt signaling in dormant oocytes | Mi et al. | 2022 | (116) | |
| iPSCs | Differentiate into ovarian epithelioid cells, increase estrogen levels and ovarian weight, decrease atretic follicles | Liu et al. | 2013 | (117) |
| OSCs | Induce the generation of follicle | White et al. | 2012 | (118) |
| ADMSCs | Protect primordial follicles from direct death, maintain quiescence through modulation of the PI3K/Akt pathway | Cacciottola et al. | 2021 | (119) |